Medical Science
Revolutionary Mass Photometry Technology Reaches Major Milestone
2025-05-12

Achieving a significant breakthrough, Refeyn, the innovator behind mass photometry technology, has successfully installed its 500th system globally within just seven years since its inception in 2018. This remarkable feat underscores the rapid adoption and transformative impact of this cutting-edge bioanalytical solution. The University of Copenhagen’s Biotech Research & Innovation Centre (BRIC) now houses the latest TwoMP mass photometer and MassFluidix HC systems, which will propel research into proteins associated with disease pathways to new heights.

The global scientific community has warmly embraced this unique technology, as evidenced by over 1,000 published studies citing mass photometry across more than 30 countries. Beyond academic institutions like the Ploug Group, biopharmaceutical companies, contract development and manufacturing organizations (CDMOs), and contract research organizations (CROs) are leveraging these tools for groundbreaking discoveries, drug development, and production processes. Dr. Michael Ploug, leader of the Ploug Group, highlights the transformative potential of mass photometry in studying intravascular lipid metabolism. Recent findings challenge previous assumptions about the composition of the LPL inhibitor ANGPTL3/8 complex, demonstrating the technology's precision and reliability even at low protein concentrations where traditional methods fall short.

Moving forward, mass photometry offers an indispensable complement to existing tools for functional and structural protein analysis. Its label-free characterization of single biomolecules and viral particles in their native state opens up vast possibilities in various fields. Applications range from analyzing bispecific antibody byproducts and lipid nanoparticles to directly measuring mRNA length and quantifying adeno-associated virus capsids. With over 1,000 scientific citations validating its capabilities, Refeyn's technology continues to inspire confidence and innovation, driving advancements that promise to reshape our understanding of biological processes and accelerate medical breakthroughs worldwide.

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