This study investigates the effectiveness and long-term outcomes of gamma knife radiosurgery (GKRS) for treating grade 2 meningiomas. Through retrospective analysis, researchers evaluated tumor control rates, progression-free survival, and identified influencing factors. Key findings indicate that GKRS can be a viable treatment option but requires higher margin doses for better local control. Patients with multiple lesions or prior recurrences face greater challenges in achieving favorable outcomes.

Assessing Long-Term Outcomes and Control Rates

Gamma knife radiosurgery has demonstrated notable success in managing grade 2 meningiomas, yet certain limitations exist. The study reveals varying control rates over time, emphasizing the need for tailored approaches based on patient characteristics. Factors such as lesion multiplicity and previous recurrence histories significantly impact results.

In-depth analysis shows that one-year, three-year, and five-year local control rates were 92%, 73%, and 65% respectively. Progression-free survival rates stood at 87%, 51%, and 44% within the same timeframe. Notably, patients with multiple lesions and those who experienced multiple prior recurrences exhibited poorer marginal control and progression-free survival. These findings suggest that personalized treatment strategies are crucial for optimizing outcomes. Moreover, the data underscores the importance of considering higher margin doses to enhance local control while minimizing risks associated with outfield progression.

Identifying Influential Factors and Clinical Implications

The research highlights critical factors affecting both tumor control and overall survival. Understanding these elements is essential for refining treatment protocols and improving patient care. Specific attention must be paid to dosage levels and lesion characteristics.

Factors such as marginal doses ≤13 Gy and the presence of multiple lesions were strongly linked to inferior local control outcomes. Furthermore, complications arose in 4% of cases, indicating the necessity for careful monitoring during GKRS procedures. To address outfield progression, particularly in high-risk patients, more aggressive treatment strategies may be warranted. This includes exploring alternative therapies or combining GKRS with other modalities. By focusing on these aspects, clinicians can develop comprehensive plans aimed at enhancing long-term efficacy and reducing recurrence rates among affected individuals.